How Much Less Should One Eat to Increase Lifespan and Reverse Brain Aging?"

 How Much Less Should One Eat to Increase Lifespan and Reverse Brain Aging?"

In the realm of cognitive health, researchers at the Buck Institute have unveiled a groundbreaking discovery focusing on how dietary restriction—eating fewer meals—can potentially defer cognitive aging and extend lifespan.

The research revealed a neuron-specific response that intensifies with low-calorie diets and intermittent fasting, a response regulated by the gene OXR1, as reported by Earth.

Dr. Kenneth Wilson, the first author of the study, remarked, “When people restrict the amount of food that they eat, they typically think it might affect their digestive tract or fat buildup, but not necessarily about how it affects the brain. As it turns out, this is a gene that is important in the brain.”

The findings indicate that dietary restriction not only diminishes the onset of neurodegenerative brain diseases but also has an impact on delaying the aging process, based on research conducted on human cells and fruit flies.

“We found a neuron-specific response that mediates the neuroprotection of dietary restriction,” shared Professor Pankaj Kapahi. “Strategies such as intermittent fasting or caloric restriction, which limit nutrients, may enhance levels of this gene to mediate its protective effects.”

Co-senior author of the study, Buck Professor Lisa Ellerby, PhD, added, “The gene is an important brain resilience factor protecting against aging and neurological diseases.”

In humans, OXR1 deficiency leads to severe neurological impairments and early mortality. Interestingly, in mice, OXR1 overexpression prolongs survival in models of ALS (Amyotrophic Lateral Sclerosis).

Through extensive testing, the research delved deeper into the connection between neurodegeneration, lifespan, and brain aging. It was revealed that OXR1 influences the retromer complex, crucial for sustaining neurons and recycling cellular lipids and proteins.

 how to age in reverse,how to live longer,reverse aging,how to never get sick again,increase lifespan,how to increase longevity,lifespan,age in reverse,how to reverse aging,how to become successful,extend lifespan,lifespan podcast,david sinclair lifespan,david sinclair reverse aging,lifespan book,dna reverse aging,how to heal your body,reverse ageing,mark hyman and dave asprey,reverse cosmetic aging,reverse your age,how to stop aging,brain aging